Rapid, Chemoenzymatic Syntheses of the Epoxyquinols (−)-Bromoxone Acetate and (−)-Tricholomenyn A

Pinkerton, DavidBanwell, MartinWillis, Anthony2015-12-070004-9425http://hdl.handle.net/1885/20536The epoxyquinol derivatives (-)-bromoxone acetate (ent-1) and (-)-tricholomenyn A (2) have been prepared from the cis-1,2-dihydrocatechols 3 and 4, respectively. Compounds 3 and 4 are themselves obtained in enantiomerically pure form through the whole-cell biotransformation of the corresponding halobenzene.Keywords: Chemo-enzymatic synthesis; Epoxyquinol; Whole-cell biotransformationsRapid, Chemoenzymatic Syntheses of the Epoxyquinols (−)-Bromoxone Acetate and (−)-Tricholomenyn A200910.1071/CH094692016-02-24