Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

Sutton, Vivien RWaterhouse, Nigel JBrowne, KylieSedelies, KarinCiccone, AnnetteAnthony, Desiree AKoskinen, AulikkiMullbacher, ArnoTrapani, Joseph A2015-12-070021-9525http://hdl.handle.net/1885/24653Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upon granule packaging. The lymphocytes of cathepsin C-null mice are therefore proposed to totally lack granzyme B activity andKeywords: dipeptidyl peptidase I; granzyme B; perforin; animal cell; animal experiment; animal model; apoptosis; article; CD8+ T lymphocyte; controlled study; Ectromelia virus; enzyme activity; enzyme inactivation; in vivo study; mouse; nonhuman; priority journal;Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis200710.1083/jcb.2006090772015-12-07