Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha

Fontes, MarcosTeh, TrazelJans, David ABrinkworth, Ross IKobe, Bostjan2015-12-132015-12-130021-9258http://hdl.handle.net/1885/75342Importin-α is the nuclear import receptor that recognizes cargo proteins carrying conventional basic monopartite and bipartite nuclear localization sequences (NLSs) and facilitates their transport into the nucleus. Bipartite NLSs contain two clusters ofKeywords: Conformations; Crystallization; Proteins; Nuclear localization sequences (NLS); Biochemistry; karyopherin alpha; phosphoprotein; phosphoprotein n1n2; retinoblastoma protein; unclassified drug; article; binding affinity; cell nucleus; crystallization; humaStructural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha200310.1074/jbc.M3032752002015-12-11