Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-Methyl-D-aspartate receptors

Kloda, AnnaClements, John DLewis, Richard JAdams, David2015-12-132015-12-130026-895Xhttp://hdl.handle.net/1885/81051ATP and glutamate are fast excitatory neurotransmitters in the central nervous system acting primarily on ionotropic P2X and glutamate [N-methyl-D-aspartate (NMDA) and non-NMDA] receptors, respectively. Both neurotransmitters regulate synaptic plasticityKeywords: adenosine diphosphate; adenosine triphosphate; cytidine triphosphate; glutamic acid; guanosine triphosphate; n methyl dextro aspartic acid receptor; neurotransmitter; purine P2X receptor; uridine triphosphate; agonist; allosterism; animal cell; article; bAdenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-Methyl-D-aspartate receptors200410.1124/mol.65.6.13862015-12-11