Liu, QingqingTao, YongfuRuan, Yong Ling2025-06-112025-06-111360-1385ORCID:/0000-0002-8394-4474/work/170600965http://www.scopus.com/inward/record.url?scp=85167991022&partnerID=8YFLogxKhttps://hdl.handle.net/1885/733759005Alkalinity constrains crop production. Recently, Zhang et al. reported a negative regulator, Alkaline Tolerance 1 (AT1), attenuating phosphorylation of plasma membrane intrinsic protein (PIP2) to block efflux of intracellular reactive oxygen species (ROS) under alkaline stress and boosting yield of cereal crops by 20–30%. However, further efforts are needed to exploit the application of AT1 in breeding alkaline-tolerant crops.This work was funded by the Australian Research Council ( DP180103834 to Y-L.R.), the National Natural Science Foundation (Excellent Young Scientists Overseas Program to Y.T. and General Funding program 31901561 to Q.L.) as well as the Henan Provincial Science and Technology Research funds ( 222102110002 to Q.L.).3enPublisher Copyright: © 2023 Elsevier Ltdalkaline toleranceaquaporinscrop productionG proteinreactive oxygen species202310.1016/j.tplants.2023.07.00485167991022