Hirayama, YuichiroKatavic, Peter L.White, Andrew M.Pierens, Gregory K.Lambert, Lynette K.Winters, Anne E.Kigoshi, HideoKita, MasakiGarson, Mary J.2025-12-162025-12-160004-9425ORCID:/0000-0002-9481-1079/work/167652636https://hdl.handle.net/1885/733795546This study reports the isolation and characterisation of six new metabolites with 'gracilin'-type carbon skeletons and of aplytandiene-3 from the Australian nudibranch Goniobranchus splendidus. The structure of gracilin G is revised, and the C-6 configuration deduced by comparison of calculated 3JC/H values with values measured using the EXSIDE pulse sequence. A lactone isolated from Goniobranchus daphne contains a rearranged spongionellin-type skeleton. Screening of selected metabolites revealed significant cytotoxicity against a HeLa S3 cell line by five of the new terpenes.9enPublisher Copyright: © CSIRO 2016.201610.1071/CH1520384957561255