Snoddy, Anne MarieMiszkiewicz, JustynaCooke, KarenPetchey, PeterBuckley, Hallie R2023-07-172472-8349http://hdl.handle.net/1885/294267Bone is dynamic, undergoing metabolic changes in response to behavioral and pathological stimuli. This information can be reconstructed in bioarchaeology using histological methods, providing another avenue to explore the experiences of past peoples. We report histological findings from midshaft femoral cortical bone of an iden-tified individual from nineteenth- century New Zealand, who suffered from tuberculosis and had a historically documented period of invalidism. Materials: Burial 21 (B21) is a middle- aged male excavated from the nineteenth- century site of St. John's burial ground, Milton. B21's left proximal femur and acetabulum exhibited lytic lesions associated with tuberculosis- induced destruction of bone. Documentation, including a cause of death of "pneu-monic phthisis haemorrhage," and various biographic details exist for this burial. These suggest that B21's left and right midshaft femur were under asymmetric biomechanical and pathological conditions and should show differences in the underlying bone remodeling. Methods: We collected data on Haversian bone microstructure geometric properties and densities from a total of 148 secondary osteons and 481 Haversian canals. Results: The left femur, from the tuberculosis-i nflicted hip joint, had fewer, larger, and more irregularly shaped canals and osteons than the right femur. Discussion and Conclusion: These findings may indicate the left femur received less biomechanical stimulation than the right femur due to decreased weightbearing. It is also possible that the tuberculosis infection in this individual impacted his bone metabolic activity, leading to increased experiences of bone loss. The presented histological approach may enhance interpretations in bioarchaeology by identifying whether bone remodeling changes occur as a result of long- or short- term disuse.This work was funded by a Marsden Fund Grant awarded to HB and PP (18-UOO- 028). Funding contributions toward technical work at the ANU histology labora-tory were from the Australian Research Council Dis-covery Early Career Research Award (DE190100068 to JJM), the ANU College of Arts and Social Sciences, and the Australian Government Research Training Program (RTP) Scholarship (to KMC)application/pdfen-AUCopyright © 2022 University of Florida Presshistologybiomechanicslimb immobilization202210.5744/bi.2021.00102022-05-08