The immunomodulatory effects of novel β-oxa, β-thia, and γ-thia polyunsaturated fatty acids on human T lymphocyte proliferation, cytokine production, and activation of protein kinase C and MAPKs

Costabile, MaurizioHii, CharlesMelino, MichelleEaston, ChristopherFerrante, Antonio2015-12-130022-1767http://hdl.handle.net/1885/76135We have recently demonstrated that a novel n-3 long chain polyunsaturated fatty acid (PUFA) (β-oxa 21:3n-3) was a more potent and more selective anti-inflammatory agent than n-3 PUFA. To gain further insights into this technology, we synthesized other noKeywords: alpha tocopherol; calcimycin; CD28 antigen; CD3 antigen; CD4 antigen; CD8 antigen; gamma interferon; indometacin; interleukin 2; lymphotoxin; mitogen activated protein kinase; monoclonal antibody; monoclonal antibody CD3; nordihydroguaiaretic acid; polyunThe immunomodulatory effects of novel β-oxa, β-thia, and γ-thia polyunsaturated fatty acids on human T lymphocyte proliferation, cytokine production, and activation of protein kinase C and MAPKs20052015-12-11