An enantioselective total synthesis of the stilbenolignan (-)-aiphanol and the determination of its absolute stereochemistry

Banwell, MartinChand, SatishSavage, G Paul2015-12-130957-4166http://hdl.handle.net/1885/76045The title natural product (-)-aiphanol has been prepared by total synthesis. A key step involved the asymmetric dihydroxylation of (E)-3,5-dimethoxy-4-(methoxymethoxy)cinnamyl alcohol with the AD-mix-β to give triol (1R,2R)-1-(3′,5′-dimethoxy-4′-meKeywords: aiphanol; stilbene derivative; unclassified drug; article; asymmetric synthesis; chemical analysis; drug synthesis; enantiomer; enantioselectivity; priority journal; stereochemistry; X ray crystallographyAn enantioselective total synthesis of the stilbenolignan (-)-aiphanol and the determination of its absolute stereochemistry200510.1016/j.tetasy.2005.02.0352015-12-11