Pathak, Rajeev K.Fahed, JoeSantangeli, PasqualeHyman, Matthew C.Liang, Jackson J.Kubala, MaciejHayashi, TatsuyaMuser, DanielePathak, ManinaKochar, ArshneelCastro, Simon A.Garcia, Fermin C.Frankel, David S.Supple, Gregory E.Schaller, Robert D.Lin, DavidRiley, Michael P.Deo, RajatEpstein, Andrew E.Zado, Erica S.Dixit, SanjayCallans, David J.Marchlinski, Francis E.2025-06-112025-06-112405-500XPubMed:30089558ORCID:/0000-0002-7391-6867/work/171152667http://www.scopus.com/inward/record.url?scp=85041560931&partnerID=8YFLogxKhttps://hdl.handle.net/1885/733759029Objectives: This study reports the long-term outcome of patients with bundle branch re-entrant tachycardia (BBRT) who underwent catheter ablation for ventricular tachycardia (VT). Background: BBRT is an uncommon mechanism of VT. Data on long-term outcomes of patients with BBRT treated with catheter ablation are insufficient. Methods: Between 2005 and 2016, 32 patients had a sustained VT due to a bundle branch re-entrant mechanism. Diagnosis of BBRT was established per standard published criteria. Results: The mode of presentation was syncope in 17 patients (53%) and palpitations in 15 (47%). BBRT was inducible in all subjects, and successful ablation of the right bundle branch in 19 patients (59%) or the left bundle branch in 13 patients (41%) was performed. During follow-up of 95 ± 36 months, 6 patients (19%) died, 3 of progressive heart failure and 3 of noncardiac causes. Recurrent VT due to BBRT did not occur in any patient. At baseline, 25 patients (78%) had a prolonged HV interval (>55 ms) and 7 (22%) had a normal HV interval (≤55 ms). In patients with a normal HV interval, there was only 1 death (due to malignancy), and no one developed heart block during 90 ± 36 months of follow-up. Ten patients (31%) had normal left ventricular (LV) function (LV ejection fraction ≥50%), and 22 (69%) had depressed LV function (LV ejection fraction <50%). No deaths were recorded in patients with normal LV function (5 with no implantable cardioverter-defibrillator) compared with 6 deaths among patients with depressed LV function (n = 22; p = 0.07). Conclusions: Radiofrequency ablation of the bundle branch is an effective therapy for treatment of BBRT. Sustained BBRT can be seen in patients with normal LV systolic function and HV interval with excellent long-term outcomes after ablation.Dr. Pathak is supported by an early career fellowship from the National Health and Medical Research Council of Australia. This work was supported in part by the Mark S. Marchlinski EP Research Fund at the University of Pennsylvania. All authors have reported that they have no relationships relevant to the contents of this paper to disclose. This study was presented as an abstract at the Heart Rhythm Society Meetings, Chicago, Illinois (May 2017).8enPublisher Copyright: © 2018 American College of Cardiology Foundationbundle branch re-entrant tachycardiacatheter ablationimplantable cardioverter-defibrillatorventricular tachycardia201810.1016/j.jacep.2017.11.02185041560931