Evaluating linkage and linkage disequilibrium: use of excess sharing and transmission disequilibrium methods in affected sib pairs

Wicks, JWilson, Susan2015-12-072015-12-070003-4800http://hdl.handle.net/1885/23811Two popular and robust approaches to analysing affected sib pair (ASP) data for linkage are the traditional excess sharing methods and the transmission/disequilibrium test (TDT). Here we derive an overall test of linkage for multi-allelic ASP marker dataKeywords: allele; article; gene linkage disequilibrium; gene locus; genetic analysis; genetic marker; genetic susceptibility; human; priority journal; probability; risk assessment; sibling; statistical analysis; technique; Genetic Diseases, Inborn; Genetic PredispoEvaluating linkage and linkage disequilibrium: use of excess sharing and transmission disequilibrium methods in affected sib pairs200010.1017/S00034800000083072015-12-07