ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

Yabas, MehmetTeh, CharisFrankenreiter, SandraLal, DennisRoots, CarlaWhittle, BelindaAndrews, Thomas DanielZhang, YafeiTeoh, NarcissusSprent, JonTze, LinaKucharska, EdytaKofler, JenniferFarrell, GeoffreyBroer, StefanGoodnow, ChristopherEnders, Anselm2015-12-081529-2908http://hdl.handle.net/1885/38103Subcompartments of the plasma membrane are believed to be critical for lymphocyte responses, but few genetic tools are available to test their function. Here we describe a previously unknown X-linked B cell-deficiency syndrome in mice caused by mutationsKeywords: adenosine triphosphatase; aminophospholipid; atp11c protein; cell protein; immunoglobulin; interleukin 7; phosphatidylserine; protein bcl 2; unclassified drug; anemia; animal cell; animal experiment; animal model; apoptosis; article; B lymphocyte; cell coATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes201110.1038/ni.20112016-02-24