Hickman, PeterKoerbin, GusSouthcott, Emma KTate, JillDimeski, GoceCarter, AndrewMcGill, DarrylTalaulikar, GirishPotter, Julia2015-12-080004-5632http://hdl.handle.net/1885/30578Background: Troponin T is present in the blood of a majority of patients with end-stage renal disease (ESRD) undergoing regular dialysis and presence of troponin T is a predictor of adverse outcome in these patients. With several new formulations of troponin I assays available, this study was performed to see whether these newer assays were able to detect troponin I in these patients more effectively than the older assays. Methods: One hundred and forty-three patients undergoing regular haemodialysis or peritoneal dialysis had plasma collected and troponin T and troponin I measured by a variety of assays. Results: The newer troponin I assays (Abbott Architect, Bayer Centaur and Beckman Accu-TnI) were able to detect troponin I (>75% of samples) as effectively as the Roche assay was able to detect troponin T, while other troponin I assays had a much lower rate of detection of troponin - DPC Immulite 2000 16% and Abbott AxSYM 35%. However, the troponin T assay had more samples detected at concentrations corresponding to an assay CV of 10% (59% of samples) than did the newer troponin I assays (highest on the Bayer Centaur at 37%). Conclusions: Newer assays demonstrate that troponin I is present in a similar number of samples as is troponin T, in the blood of patients with dialysis-dependent renal failure, and these newer troponin I assays identify patients at risk of experiencing a cardiac event.Keywords: troponin I; troponin T; adolescent; adult; aged; article; blood sampling; clinical effectiveness; hemodialysis; hemodialysis patient; human; intermethod comparison; kidney failure; major clinical study; peritoneal dialysis; priority journal; protein deter200710.1258/0004563077804808552015-12-08