Gas-phase ion-molecule reactions using regioselectively generated radical cations to model oxidative damage and probe radical sites in peptides

Barlow, Christopher KWright, AdamEaston, ChristopherO'Hair, Richard A J2015-12-101477-0520http://hdl.handle.net/1885/58631Collision induced dissociation (CID) of sodiated peptide derivatives containing a nitrate ester functionality was used to regiospecifically generate three isomeric radicals of the model peptide Bz-Ala-Gly-OMe corresponding to radicals formed at: Cα of thKeywords: 4-Fluorothiophenol; Alanine residues; Collision induced dissociation; Gasphase; Glycine residues; Hydrogen atoms; Hydroperoxides; Intramolecular hydrogen; Ion-molecule reaction; Model peptides; Nitrate esters; Oxidative damage; Peroxyl radical; Radical caGas-phase ion-molecule reactions using regioselectively generated radical cations to model oxidative damage and probe radical sites in peptides201110.1039/c0ob01245a2016-02-24