Potter, JuliaSimpson, Aaron J.Kerrigan, Jennifer LSouthcott, EmmaSalib, Marie MKoerbin, GHickman, Peter2022-06-150009-9120http://hdl.handle.net/1885/267284Objectives: While persons with overt renal failure have a well-described rise in troponin and NT-proBNP, it is less well described what the relationship is between cardiac markers and persons with impaired renal function, not requiring dialysis. Design & methods: We have collected ALL samples referred to our pathology practice over a 24 h period and measured hs-cTnI, hs-cTnT, NT-proBNP, calculated the eGFR, and related our measurements to clinical outcomes. Results: For both men and women, for all of hs-cTnI, hs-cTnT and NT-proBNP, there was a graded response, as renal function worsened, the concentration of the cardiac marker increased. Conclusions: There is a graded inverse relationship between eGFR and the concentrations of hs-cTnI, hs-cTnT and NT-proBNP. For women only there appeared to be an increase in mortality at lowest eGFRapplication/pdfen-AU© 2017 The Canadian Society of Clinical Chemists. Published by Elsevier IncCardiac troponinNT-proBNPeGFR201710.1016/j.clinbiochem.2017.04.0032021-02-14