Binding inhibitors of the bacterial sliding clamp by design

Wijffels, GeneJohnson, Wynona MOakley, AaronTurner, KathleenEpa, V ChandanaBriscoe, Susan JPolley, MitchellLiepa, Andris JHofmann, AlbertBuchardt, JensChristensen, CasparProsselkov, PavelDalrymple, Brian PaulAlewood, Paul FJennings, Phil ADixon, NicholasWinkler, David A2015-12-100022-2623http://hdl.handle.net/1885/59270The bacterial replisome is a target for the development of new antibiotics to combat drug resistant strains. The β2 sliding clamp is an essential component of the replicative machinery, providing a platform for recruitment and function of other replisomaKeywords: bacterial DNA; bacterial sliding clamp; biphenyl; biphenyl oxime; replisome; unclassified drug; article; binding affinity; binding site; carboxy terminal sequence; crystal structure; DNA binding motif; DNA repair; DNA replication; pharmacophore; protein mBinding inhibitors of the bacterial sliding clamp by design201110.1021/jm20043332016-02-24