Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

Randall, KatrinaLambe, TeresaJohnson, Andy LTreanor, BebhinnKucharska, EdytaDomaschenz, HeatherWhittle, BelindaTze, LinaEnders, AnselmCrockford, TanyaBouriez-Jones, TiphaineAlston, DuncanCyster, Jason GLenardo, Michael J.Mackay, FabienneDennick, Elissa K.Tangye, StuartChan, Tyani D.Camidge, TahraBrink, RobertGarcia De Vinuesa, Maria CarolaBatista, Facundo D.Cornall, Richard JGoodnow, Christopher2015-12-081529-2908http://hdl.handle.net/1885/33188To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified hadKeywords: B lymphocyte receptor; intercellular adhesion molecule 1; protein Dock8; Rac protein; Rho factor; unclassified drug; animal cell; animal experiment; animal model; antibody production; antibody response; article; B lymphocyte; cell survival; controlled stuDock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production200910.1038/ni.18202016-02-24