Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic beta-Cell at Submaximal Glucose Concentrations

Lamontagne, JulienPepin, EmiliePeyot, Marie-LineJoly, ErikRuderman, NeilPoitout, VincentMadiraju, Murthy S RNolan, ChristopherPrentki, Marc2015-12-100013-7227http://hdl.handle.net/1885/38830Thiazolidinediones (TZDs) have beneficial effects on glucose homeostasis via enhancement of insulin sensitivity and preservation of β-cell function. How TZDs preserve β-cells is uncertain, but it might involve direct effects via both peroxisome proliferKeywords: adenosine triphosphate; antidiabetic agent; berberine; compound c; enzyme inhibitor; fatty acid; glucose; hydroxymethylglutaryl coenzyme A reductase kinase; metformin; palmitic acid; pioglitazone; unclassified drug; animal cell; article; controlled study;Pioglitazone Acutely Reduces Insulin Secretion and Causes Metabolic Deceleration of the Pancreatic beta-Cell at Submaximal Glucose Concentrations200910.1210/en.2008-15572016-02-24