Lipnicki, DarrenMakkar, SteveCrawford, JohnThalamuthu, AnbupalamKochan, Nicole A.Lima-Costa, Maria FernandaCastro-Costa, EricoBrayne, CarolPinheiro Ferri, CleusaStephan, Blossom C. M.Anstey, KaarinCherbuin, Nicolas2020-01-082020-01-08Lipnicki DM, Makkar SR, Crawford JD, Thalamuthu A, Kochan NA, Lima-Costa MF, et al. (2019) Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study. PLoS Med 16 (7): e1002853. https://doi.org/10.1371/journal. pmed.10028531549-1277http://hdl.handle.net/1885/196646With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and late-life cognitive decline on a global scale, including comparisons between ethno-regional groups.Funding for COSMIC comes from a National Health and Medical Research Council of Australia Program Grant (ID 1093083) (PSS, HB), the National Institute On Aging of the National Institutes of Health under Award Number RF1AG057531 (PSS, MG, RBL, KR, KWK, HB), and philanthropic contributions to The Dementia Momentum Fund (UNSW Project ID PS38235) (PSS, HB). Funding for each of the contributing studies is as follows: The Brazilian Ministry of Health (Department of Science and Technology), the Brazilian Ministry of Science and Technology (National Fund for Scientific and Technological Development, Funding of Studies, Brazilian National Research Council) and the Minas Gerais State Research Foundation (MFLC, ECC); Major awards from the Medical Research Council and the Department of Health, UK (CB); The Wellcome Trust Foundation (GR066133 and GR08002) and the Cuban Ministry of Public Health (JJLR); Supported in part by National Institutes of Health grants NIA 2 P01 AG03949, the Leonard and Sylvia Marx Foundation, and the Czap Foundation (RBL, MJK); Novartis (KR, MLA); IIRG-09133014 from the Alzheimer’s Association; 189 10276/8/9/2011 from the ESPA-EU program Excellence Grant (ARISTEIA), which is co-funded by the European Social Fund and Greek National resources, and ΔY2β/οικ.51657/14.4.2009 from the Ministry for Health and Social Solidarity (Greece) (NS); The Mei Family Trust (LL); Financed with own funds and supported in part by "Federazione Alzheimer Italia", Milan, Italy (AG); The Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea [Grant No. HI09C1379 (A092077)] (KWK); The Interdisciplinary Centre for Clinical Research at the University of Leipzig (Interdisziplina¨res Zentrum fu¨r Klinische Forschung/IZKF; grant 01KS9504) (SGRH); Grant # R01AG07562 from the National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services (MG); National Health and Medical Research Council of Australia grants 973302, 179805, 157125 and 1002160 (KA); NIH grants AG12975, T32 AG049663, ES023451 (MNH); Carolina Population Center (CPC) Funding: CPC Center grant (the P2C Center grant from NIH): P2C HD050924. CPC NICHD-NRSA Population Research Training (the T32 Training grant from NIH): T32 HD007168, Biosocial Training Grant: T32 HD091058 (AEA); JSPS KAKENHI Grant Number JP17K09146 (SK); Agency for Science Technology and Research (A-STAR) Biomedical Research Council (BMRC) [Grants: 03/1/21/17/214 and 08/1/21/19/567] and the National Medical Research Council [Grant: NMRC/1108/2007] (TPN); The Wellcome Trust Foundation and FAPESP, São Paulo, Brazill (MS); National Health & Medical Research Council of Australia Program Grant (ID 350833) (PSS, HB); Supported by grants from the Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competitiveness, Madrid, Spain (grants 94/1562, 97/1321E, 98/0103, 01/0255, 03/0815, 06/0617, G03/128), and the Fondo Europeo de Desarrollo Regional (FEDER) of the European Union and Gobierno de Arago´n, Group #19 (AL).application/pdfen-AU© 2019 Lipnicki et al.https://creativecommons.org/licenses/by/4.0/2019-07-2310.1371/journal.pmed.10028532019-08-25Creative Commons Attribution License