Jackson, ColinLiu, Jian-WeiCarr, Paul DYounus, FaisalCoppin, Christopher WMeirelles Betancur, TamaraLethier, MathildePandey, GunjanOllis, DavidRussell, Robyn JWeik, MartinOakeshott , John2015-12-130027-8424http://hdl.handle.net/1885/73077Insect carboxylesterases from the αEsterase gene cluster, such as αE7 (also known as E3) from the Australian sheep blowfly Lucilia cuprina (LcαE7), play an important physiological role in lipid metabolism and are implicated in the detoxification of orgAuthor/s retain copyrightKeywords: acetylcholinesterase; alpha carboxylesterase; carboxylesterase; hydrolase; unclassified drug; alpha helix; article; crystal structure; enzyme active site; enzyme specificity; enzyme substrate complex; Escherichia coli; hydrophobicity; insecticide resistan Ali-esterase; Directed evolution; Protein engineeringStructure and function of an insect α-carboxylesterase (α Esterase 7) associated with insecticide resistance201310.1073/pnas.13040971102016-02-24