Ramiscal, Roybel RVinuesa, Carola2014-02-192014-02-190105-2896http://hdl.handle.net/1885/11394T cells are known to migrate to B-cell-enriched follicles and germinal centers within secondary lymphoid organs to provide help to B cells. Cognate T:B interactions that take place at the T:B border and subsequently within germinal centers are essential for B-cell priming, differentiation into germinal center B cells, and selection of mutated cells into memory B cells or memory plasma cells. In recent years, different stages of maturation within B-cell helper T cells, collectively known as B-follicular helper T (Tfh) cells, as well as heterogeneity amid germinal center T cells are becoming clear. Indeed, germinal centers support not only bona fide Tfh cells but also CD4+ and CD8+ follicular regulatory T (Tfr) cells that act to suppress germinal center responses and B-cell helper natural killer T cells. There is a growing need for more precise phenotypic and functional distinction of these specialized T-cell subsets. In this review, we summarize current knowledge on the ontogeny, molecular identity, and functional relevance of the various subsets of germinal center T cells.10 pageshttp://www.sherpa.ac.uk/romeo/issn/0105-2896/author can archive pre-print (ie pre-refereeing); author cannot archive publisher's version/PDF; subject to rstrictions, author can archive post-print (ie final draft post-refereeing) - refer to publisher website. (Sherpa/Romeo as at19/2/14)T cellsB cellscell differentiationlineage commitmenttolerancecytokines2013-02-1310.1111/imr.120312015-12-11