Jeziorowski, AnneGordon, David2015-12-100021-9193http://hdl.handle.net/1885/49470Survey results and genotypic characterization of Escherichia coli strains demonstrate that the baeteriocins colicin Ia and microcin V coassociate in a strain more often than would be expected by chance. When these two baeteriocins co-occur, they are encoded on the same conjugative plasmid. Plasmids encoding colicin Ia and microcin V are nonrandomly distributed with respect to the genomic background of the host strain. Characterization of microcin V and colicin Ia nucleotide variation, together with the backbone of plasmids encoding these baeteriocins, indicates that the association has evolved on multiple occasions and involves the movement of the microcin V operon, together with the genes iroNEDCB and iss, onto a nonrandom subset of colicin Ia plasmids. The fitness advantage conferred on cells encoding both colicin Ia and microcin V has yet to be determined.Keywords: bacteriocin; colicin; colicin 1a; microcin V; unclassified drug; amino acid sequence; article; bacterial strain; Escherichia coli; evolution; genomics; nonhuman; nucleotide sequence; operon; plasmid; priority journal; sequence analysis; Bacteriocins; Coli200710.1128/JB.00243-072015-12-09