Ma, XinghuaJury, JasmineBanwell, Martin2015-12-100040-4039http://hdl.handle.net/1885/59286A chemoenzymatic synthesis of the putative biogenetic precursor, 6, to the epoxy-quinol type natural products, tricholomenyns B, C, D and E (2-5, respectively), has been achieved. However, treatment of compound 6 under a variety of conditions failed to effect its conversion into any of the natural products 2-5. In contrast, the simple model system 22 reacts with acetic acid in the presence of stoichiometric quantities of Ti(OPr-i)4 to give the diacetate 23.Keywords: acetic acid; acetoacetic acid; natural product; tricholomenyn b; tricholomenyn c; tricholomenyn d; tricholomenyn e; unclassified drug; article; stoichiometry; synthesis Chemoenzymatic; Epoxy-quinol; Sonogashira reaction; Synthesis; Tricholomenyns201110.1016/j.tetlet.2010.11.1392016-02-24