Identification and Characterization of gamma-Glutamylamine Cyclotransferase, an Enzyme Responsible for gamma-Glutamyl-epsilon-lysine Catabolism

Oakley, AaronCoggan, MarjorieBoard, Philip2015-12-070021-9258http://hdl.handle.net/1885/17780γ-Glutamylamine cyclotransferase (GGACT) is an enzyme that converts γ-glutamylamines to free amines and 5-oxoproline. GGACT shows high activity toward γ-glutamyl-ε-lysine, derived from the breakdown of fibrin and other proteins cross-linked by transglKeywords: Active site; Different substrates; Enzymatic activities; Free amines; High activity; Sequence identity; Three-dimensional structure; Transglutaminases; Amination; Amino acids; Catalysts; Enzymes; Organic acids; Plants (botany); Enzyme activity; 6 (gamma gIdentification and Characterization of gamma-Glutamylamine Cyclotransferase, an Enzyme Responsible for gamma-Glutamyl-epsilon-lysine Catabolism201010.1074/jbc.M109.0820992016-02-24