Freeman, CraigZiolkowski, AndrewHe, Y.Q.Sutcliffe, Elissa LZafar, AnjumRao, SudhaSimeonovic, CharmaineParish, Christopher2015-12-130945-053Xhttp://hdl.handle.net/1885/84666Heparanase (Hpse) is an endo-β-. d-glucuronidase that degrades the glycosaminoglycan heparan sulfate (HS) in basement membranes (BMs) to facilitate leukocyte migration into tissues. Heparanase activity also releases HS-bound growth factors from the extraKeywords: free radical; heparanase; histone H3; lysine; microRNA; pi 88; animal experiment; animal model; catalysis; cell adhesion; cell death; cell invasion; cell nucleus; cell surface; cell survival; disease course; enzyme activity; female; gene control; gene tar Basement membrane; Gene transcription; Heparan sulfate; Heparanase; Leukocyte migration; Type 1 diabetes201310.1016/j.matbio.2013.02.0072016-02-24