Matuschewski, KaiMaier, Alexander2023-06-261471-4922http://hdl.handle.net/1885/293694The molecular arms race between humans and Plasmodium falciparum in Africa resulted in selection of sickle-cell disease, which, on balance, protects heterozygote carriers against severe malaria. Band et al. discovered that parasites counter-adapt and can overcome disease resistance by identifying parasite genome signatures, termed P. falciparum sickle-associated (Pfsa) variants.The authors are supported by the Alliance Berlin Canberra 'Crossing Boundaries: Molecular Interactions in Malaria', which is cofunded by a grant from the Deutsche Forschungsgemeinschaft (DFG) for the International Research Training Group (IRTG) 2290 and the Australian National University, and the Australian Research Council (DP180103212 to A.G.M.)application/pdfen-AU© 2022 Elsevier Ltd.202210.1016/j.pt.2022.01.0092022-04-03