Mahalingam, SurendranKarupiah, Gunasegaran2015-12-130818-9641http://hdl.handle.net/1885/89314MuMig (monokine induced by gamma interferon) and Crg-2 (cytokine responsive gene) are chemokines of the CXC subfamily. They share activity as T and NK cell chemoattractants. Crg-2 has been shown to be inducible by IFN, TNF, IL-1 and LPS, whereas the expression of MuMig is thought to be strictly dependent on IFN-γ. In the present study, the kinetics of expression of the genes for MuMig and Crg-2 were analysed by northern blot analysis in organs of normal mice and in groups of gene knockout mice deficient in IFN-γ (IFN- γ-/-) or receptors for IFN-α/β and IFN-γ (double R(-/-); DR+) after vaccinia virus infection. MuMig mRNA was not expressed in IFN-γ(-/-) mice in all organs examined, whereas Crg-2 mRNA levels were marginally reduced. In contrast, MuMig and Crg-2 mRNA transcripts were completely abolished in the DR(-/-) mice.Keywords: chemokine; gamma interferon; interferon; interferon inducing agent; interleukin 1; lipopolysaccharide; monokine; tumor necrosis factor; animal experiment; animal model; animal tissue; article; controlled study; cytokine responsive element; gene activation Chemokine; Interferon; Vaccinia virus200010.1046/j.1440-1711.2000.00894.x2015-12-12