Longley, Rhea J.White, Michael T.Brewster, JessicaLiu, Zoe S.J.Bourke, CaitlinTakashima, EizoHarbers, MatthiasTham, Wai HongHealer, JulieChitnis, Chetan E.Monteiro, WueltonLacerda, MarcusSattabongkot, JetsumonTsuboi, TakafumiMueller, Ivo2025-06-122025-06-122328-8957ORCID:/0000-0001-7950-8699/work/218987871http://www.scopus.com/inward/record.url?scp=85118669660&partnerID=8YFLogxKhttps://hdl.handle.net/1885/733760096To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.5enPublisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.antibodyIgGIgMmalariaPlasmodium vivaxserological exposure markersserologysurveillance2021-05-2210.1093/ofid/ofab22885118669660