Jimenez-Donaire, Maria J.Cormier, DianeBigiel, FrankLeroy, Adam KGallagher, MollyKrumholz, MarkUsero, AntonioHughes, AnnieKramer, CarstenMeier, DavidMurphy, EricPety, JeromeSchinnerer, EvaSchruba, AndreasSchuster, KarlSliwa, KazimierzTomicic, Neven2021-04-232041-8205http://hdl.handle.net/1885/230985We use the IRAM Large Program EMPIRE and new high-resolution ALMA data to measure 13CO(1-0)/C18O(1-0) intensity ratios across nine nearby spiral galaxies. These isotopologues of 12CO are typically optically thin across most of the area in galaxy disks, and this ratio allows us to gauge their relative abundance due to chemistry or stellar nucleosynthesis effects. Resolved 13CO/C18O gradients across normal galaxies have been rare due to the faintness of these lines. We find a mean 13CO/C18O ratio of 6.0 ± 0.9 for the central regions of our galaxies. This agrees well with results in the Milky Way, but differs from results for starburst galaxies (3.4 ± 0.9) and ultraluminous infrared galaxies (1.1 ± 0.4). In our sample, the 13CO/C18O ratio consistently increases with increasing galactocentric radius and decreases with increasing star formation rate surface density. These trends could be explained if the isotopic abundances are altered by fractionation; the sense of the trends also agrees with those expected for carbon and oxygen isotopic abundance variations due to selective enrichment by massive stars.F.B., M.J., and D.C. acknowledge support from DFG grant BI 1546/1-1. A.H. acknowledges support from the Centre National d’Etudes Spatiales (CNES). A.U. acknowledges support from Spanish MINECO grants FIS2012-32096 and ESP2015-68964. The work of A.K.L. is partially supported by the National Science Foundation under grants No. 1615105 and 1615109. M.R.K. acknowledges support from ARC DP160100695. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. This paper makes use of the following ALMA data: ADS/JAO. ALMA #2011.0.00004.SV. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada), NSC and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO and NAOJ.application/pdfen-AU© 2017. The American Astronomical Societygalaxies: ISMISM: moleculesradio lines: galaxies¹³CO/C¹⁸O Gradients across the Disks of Nearby Spiral Galaxies201710.3847/2041-8213/836/2/L292020-11-23