Chemoenzymatic approaches to the montanine alkaloids: a total synthesis of (+)-brunsvigine

Banwell, MartinKokas, OkanyaWillis, Anthony2015-12-081523-7060http://hdl.handle.net/1885/33228The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].Keywords: alkaloid; Amaryllidaceae alkaloid; brunsvigine; catechol derivative; isoquinoline derivative; montanine; unclassified drug; article; chemical structure; chemistry; stereoisomerism; synthesis; Alkaloids; Amaryllidaceae Alkaloids; Catechols; Isoquinolines;Chemoenzymatic approaches to the montanine alkaloids: a total synthesis of (+)-brunsvigine200710.1021/ol071344y2015-12-08