Seymour, MikeRuster, LorennPeter, SandraRiemer, KaiKautz, Karlheinz2026-07-032026-07-031529-3181ORCID:/0000-0002-4267-7680/work/219175209https://hdl.handle.net/1885/733812899This paper examines how the Information Systems (IS) discipline can meaningfully engage with the emerging landscape of artificial intelligence (AI), drawing on insights from two expert panels convened at the Australasian Conference on Information Systems (ACIS) in late 2023 and 2024. These panels, comprising scholars at varying academic stages, interrogated the foundational differences between AI and earlier digital technologies studied by IS, particularly AI’s probabilistic, data-driven, and anthropomorphic nature. We argue that IS, with its long-standing sociotechnical orientation and interdisciplinary breadth, is uniquely positioned to address AI’s complex societal implications. However, doing so requires theoretical renewal, methodological adaptation toward anticipatory research, and institutional reform to enable faster, more relevant publishing. This paper outlines these challenges, presents pathways for disciplinary renewal, and calls on IS scholars to embrace their role in shaping responsible, human-centered AI. The discussion contributes to repositioning IS as an essential voice in global conversations on the design, deployment, and governance of AI technologies and IS researchers as key participants in shaping how AI technologies are responsibly integrated into the future.22enPublisher Copyright: © 2025 by the Association for Information Systems.Artificial IntelligenceDataInformation Systems202510.17705/1CAIS.05757105023830453