Lesage, SylvieHartley, SuzanneAkkaraju, SrinivasWilson, JudithTownsend, MichelleGoodnow, Christopher2015-12-130022-1007http://hdl.handle.net/1885/94668Type 1 diabetes and other organ-specific autoimmune diseases often cluster together in human families and in congenic strains of NOD (nonobese diabetic) mice, but the inherited immuno-regulatory defects responsible for these diseases are unknown. Here weKeywords: autoantibody; CD4 antigen; immunoglobulin G antibody; immunoglobulin G1; major histocompatibility antigen; animal cell; animal model; article; autoimmune disease; autoimmunity; diabetes mellitus; disease predisposition; flow cytometry; genetic susceptibil Autoimmune disease; Clonal deletion; Diabetes mellitus type I; Genetic predisposition to disease; T lymphocytes200210.1084/jem.200207352015-12-12