Microwave-assisted trans -halogenation reactions of various chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines, isoquinolines, and pyridines leading to the corresponding iodinated heterocycles

Bissember, AlexanderBanwell, Martin2015-12-100022-3263http://hdl.handle.net/1885/55143(Chemical Equation Presented) Microwave irradiation of certain chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines in the presence of acetic anhydride and sodium iodide leads, via a trans-halogenation process, to the corresponding iodides in high yield. Related conversions involving pyridines and isoquinolines can also be achieved under similar conditions.Keywords: Acetic anhydrides; Chemical equations; Heterocycles; High yield; Isoquinolines; Microwave-assisted; Sodium iodides; Halogenation; Pyridine; Sodium; Microwave irradiation; acetic anhydride; heterocyclic compound; isoquinoline derivative; methyl bromide; meMicrowave-assisted trans -halogenation reactions of various chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines, isoquinolines, and pyridines leading to the corresponding iodinated heterocycles200910.1021/jo90083862016-02-24