A new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation

Jenne, CKennedy, LMcCullagh, PeterReynolds, J2015-12-132015-12-130022-1767http://hdl.handle.net/1885/88305The current model of Ig repertoire development in sheep focuses on the rearrangement of a small number (∼20) of Vλ gene segments. It is believed that this limited combinatorial repertoire is then further diversified through postrearrangement somatic hyKeywords: immunoglobulin; animal cell; animal tissue; article; combinatorial chemistry; controlled study; gene mutation; gene rearrangement; genetic variability; nonhuman; nucleotide sequence; priority journal; sheep; somatic hypermutation; Aging; Amino Acid SequenA new model of sheep Ig diversification: shifting the emphasis toward combinatorial mechanisms and away from hypermutation20032015-12-12