Selective modulation of different GABA(A) receptor isoforms by diazepam and etomidate in hippocampal neurons

Seymour, VictoriaCurmi, JohnHowitt, SusanCasarotto, MarcoLaver, Derek RowlandTierney, Mary (Louise)2015-12-101357-2725http://hdl.handle.net/1885/54700Diazepam modulation of native γ2-containing GABAA (γGABAA) receptors increases channel conductance by facilitating protein interactions involving the γ2-subunit amphipathic (MA) region, which is found in the cytoplasmic loop between transmembrane domaiKeywords: 4 aminobutyric acid A receptor; diazepam; etomidate; gamma (392 422) MA peptide; peptide; unclassified drug; amino acid sequence; animal cell; article; brain nerve cell; controlled study; drug protein binding; female; hippocampus; ion conductance; male; n Amphipathic region; Diazepam; Etomidate; GABAA receptor; Ion channel; Protein interactions; Single-channel recordingSelective modulation of different GABA(A) receptor isoforms by diazepam and etomidate in hippocampal neurons201210.1016/j.biocel.2012.06.0012016-02-24