Woodberry, ToniaBouffler, SophieWilson, AliciaBuckland, RebeccaBruestle, Anne2023-07-032023-07-032077-0383http://hdl.handle.net/1885/293899Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a strong autoimmune, neurodegenerative, and neuroinflammatory component. Most of the common disease modifying treatments (DMTs) for MS modulate the immune response targeting disease associated T and B cells and while none directly target neutrophils, several DMTs do impact their abundance or function. The role of neutrophils in MS remains unknown and research is ongoing to better understand the phenotype, function, and contribution of neutrophils to both disease onset and stage of disease. Here we summarize the current state of knowledge of neutrophils and their function in MS, including in the rodent based MS model, and we discuss the potential effects of current treatments on these functions. We propose that neutrophils are likely to participate in MS pathogenesis and their abundance and function warrant monitoring in MS.This research was funded by Multiple Sclerosis Research Australia project grant 16-122 and has been delivered in partnership with Our Health in Our Hands, a strategic initiative of the Australian National University, which aims to transform healthcare by developing new personalized health technologies and solutions in collaboration with patients, clinicians, and health care providers.This research is supported by an Australian Government Research Training Program (RTP) Scholarship (A.S.W. and R.L.B.) and a Fenner Merit Scholarship in Medical Sciences (R.L.B.).application/pdfen-AU© 2018 The authorshttp://creativecommons.org/licenses/by/4.0/201810.3390/jcm71205112022-04-10Creative Commons Attribution licence