Mould, ArnePang, ZhenyiPakusch, MihaTonks, Ian D.Stark, MitchellCarrie, DianneMukhopadhyay, PamelaSeidel, AnnicaEllis, Jonathan J.Deakin, JanineWakefield, MatthewKrause, LutzBlewitt, Marnie EKay, Graham F.2015-12-131756-8935http://hdl.handle.net/1885/73986Background: Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking Smchd1 fail during midgestational development. Male mice are less affected by Smchd1-loss, with some (but not all) surviving to become fertile aduKeywords: cadherin; cell protein; protocadherin alpha; protocadherin beta; protocadherin gamma; Smchd1 protein; unclassified drug; article; autosomal disorder; biallelic expression; chromosome; CpG island; embryo development; epigenetics; gene cluster; gene disrupt Clustered protocadherins; Genomic imprinting; Monoallelic expression; Smchd1; X inactivation201310.1186/1756-8935-6-192016-02-24