Lade, Steven2015-12-100375-9601http://hdl.handle.net/1885/51907Large sampling intervals can affect reconstruction of Kramers-Moyal coefficients from data. A new method, which is direct, non-stochastic and exact up to numerical accuracy, is developed to estimate these finite time effects. The method is applied numerically to biologically inspired examples. Exact finite time effects are also described analytically for two special cases. The approach developed will permit better evaluation of Langevin or Fokker-Planck based models from data with large sampling intervals. It can also be used to predict the sampling intervals for which finite time effects become significant.Keywords: Adjoint operator; Finite sampling interval; Fokker-Planck equation; Kramers-Moyal coefficients; Molecular motors; Tethered diffusion200910.1016/j.physleta.2009.08.0292016-02-24