Chai, ChristinaElix, JohnHuleatt, Paul2015-12-132015-12-130040-4039http://hdl.handle.net/1885/76375Mild methods for controlled C- and N-alkylation of 3-benzyloxycarbonylpiperazine-2,5-diones are reported. The benzyloxylcarbonyl substituent can also serve as latent functionality for N-acyliminium ion formation and subsequent trapping enables installation of new carbon and/or heteroatom substituents.Keywords: 2,5 piperazinedione; piperazine derivative; unclassified drug; alkylation; article; chemical structure Alkylations; Amino acids and derivatives; N-acyliminium ions; Trapping reactionsMulti-purpose functionality for the structural elaboration of the piperazine-2,5-dione motif200310.1016/S0040-4039(02)02571-62015-12-11