Gao, QiJiang, BaofaTong, MichaelZuo, HuiCheng, ChuanlongZhang, YuqiSong, SihaoLu, LiangLi, Xiujun2026-06-112026-06-110304-3894PubMed:40058198ORCID:/0000-0002-9694-9207/work/217150189https://hdl.handle.net/1885/733810704Influenza imposes a significant global health burden. This study investigates the effects of humidex and air pollution on influenza and their interactions, using multi-city surveillance data in China. Daily data on reported influenza cases, meteorological factors and air pollution from 319 cities in mainland China over the study period of 2014–2019 were collected. A two-stage analytical framework, comprising distributed lag non-linear model and multivariate meta-analysis, was employed to assess the associations between humidex, air pollution and influenza. Hierarchical and joint effect models were employed to examine their interaction. Nationally, an approximately L-shaped relationship between humidex and influenza was observed, with the highest relative risk (RR) of 2.603 (95 % confidence interval [CI]: 2.195–3.086). Per interquartile range increases in PM2.5, PM10, NO2, SO2, CO and O3 were associated with influenza risk increments of 0.035 (95 % CI: 0.010–0.061), 0.029 (95 % CI: 0.003–0.055), 0.191 (95 % CI: 0.152–0.231), 0.239 (95 % CI: 0.166–0.317), 0.038 (95 % CI: 0.001–0.076) and −0.171 (95 % CI: −0.238–0.099), respectively. A synergistic interaction effect was identified between low humidex and high air pollution as well as different air pollutants. Subgroup analyses indicated females and individuals aged 7–18 years old exhibited higher risks. Stronger effects were observed during winter season and in large cities. This study underscores the urgent need for tailored interventions to mitigate the health impacts in regions with concurrent low humidex and high air pollution.This study was supported by National Key Research and Development Program of China [grant numbers: 2023YFC2604400] and the Special Foundation of Basic Science and Technology Resources Survey of Chinese Ministry of Science and Technology [grant numbers: 2017FY101202].enPublisher Copyright: © 2025 Elsevier B.V.Air pollutionHumidexInfluenzaInteraction effect2025-06-1510.1016/j.jhazmat.2025.13786586000310824