Kirk, KiaranHowitt, SusanBroer, StefanSaliba, KevinDownie, Megan2015-12-101471-4922http://hdl.handle.net/1885/51077In a recent paper, Quashie et al. have proposed that purine uptake into the intraerythrocytic malaria parasite involves four different plasma membrane transporters - two high affinity and two low affinity. They equate one of the two high-affinity transporters with PfNT1, a transporter reported previously to be a low-affinity system. Here, we offer an alternative interpretation of their data, suggesting that the conclusions drawn by Quashie et al. take insufficient account of metabolism.Keywords: adenine; adenosine; hypoxanthine; inosine; nucleic acid base; nucleoside transporter; purine; pyrimidine; thymidine; cell membrane; cell metabolism; erythrocyte; experiment; malaria; nonhuman; Plasmodium; Plasmodium falciparum; short survey; Animals; Biol200910.1016/j.pt.2009.03.0062016-02-24