3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations

Banwell, MartinCoster, MarkHungerford, NatashaGarson, Mary JSu, StephenKotze, AndrewMunro, Murray HG2015-12-101477-0520http://hdl.handle.net/1885/60550Compounds 2-5, incorporating various elements of the 3,4′- bis(piperidine) core associated with the sponge-derived alkaloid haliclonacyclamine A (HA, 1), have been prepared through, inter alia, aldol-type reactions of N-substituted piperidin-4-ones andKeywords: Biological evaluation; Marine alkaloids; Nitrogen compounds; Metabolites3,4'-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations201210.1039/C1OB06418E2016-02-24