A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants

Ejehi, ZeinabAriafard, Alireza2025-06-112025-06-111359-7345PubMed:28079213ORCID:/0000-0003-2383-6380/work/163628651http://www.scopus.com/inward/record.url?scp=85010297188&partnerID=8YFLogxKhttps://hdl.handle.net/1885/733758705It is widely reported that the Pt(iv) prodrugs with two axial chlorido ligands are reduced by biological reductants via a chloride-bridged inner-sphere mechanism. By contrast, in this contribution, we demonstrate that although this approach might be true for the reductants with sulphur donors, the reduction by ascorbates preferentially occurs via an outer sphere mechanism.4enPublisher Copyright: © The Royal Society of Chemistry 2017.A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants201710.1039/c6cc07834f85010297188