Delerue, FabienSjollema, GeoffreyWhittle, BelindaKruger, SarahAndrews, DanGotz, Jurgen2015-12-132090-0252http://hdl.handle.net/1885/73208One of the major challenges in neurodegenerative research is modeling systemic aging. Here, senescence-accelerated mice such as the multigenic SAMP8 (senescence accelerated prone 8) mice are useful as they are characterized by an early manifestation of seAuthor/s retain copyrightKeywords: aging; Alzheimer disease; animal experiment; animal model; animal tissue; article; brain dysfunction; controlled study; exome; gene mutation; gene sequence; genotype; immune dysregulation; lifespan; mouse; nerve degeneration; nonhuman; phenotype; priority Alzheimer's disease; exome sequencing; mouse; senescence; sequence nucleotide variants201310.3233/JAD-1300892016-02-24