Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn 2+ chelation

Jones, AllisonHulett, MarkParish, Christopher2015-12-132015-12-130021-9258http://hdl.handle.net/1885/77728Histidine-rich glycoprotein (HRG) is an α2-glycoprotein found in mammalian plasma at high concentrations (∼150 μg/ml) and is distinguished by its high content of histidine and proline. Structurally, HRG is a modular protein consisting of an N-terminalKeywords: Biochemistry; Cells; Chemical bonds; Cytology; Physiology; Fibrinogen; Glycoproteins; Proteins; adaptor protein; alpha2 glycoprotein; chondroitin ABC lyase; complement component C1q; cystatin; fibrinogen; glycosaminoglycan; heparan sulfate; heparanase; heHistidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn 2+ chelation200410.1074/jbc.M4019962002015-12-11