Evidence That the Coactivator CBP/p300 Is Important for Phenobarbital-Induced but Not Basal Expression of the CYP2H1 Gene

Dogra, SatishTremethick, DavidMay, Fiona J2015-12-130026-895Xhttp://hdl.handle.net/1885/92331We have previously identified an upstream 556-bp enhancer domain for the chicken CYP2H1 gene that responds to phenobarbital and binds several transcription factors, including the orphan chicken xenobiotic receptor (CXR). By contrast, the promoter lacks aKeywords: cyclic AMP responsive element binding protein; cytochrome P450; histone deacetylase inhibitor; messenger RNA; phenobarbital; protein p300; trichostatin A; animal cell; article; cell assay; chick embryo; chromatin; controlled study; drug response; embryo;Evidence That the Coactivator CBP/p300 Is Important for Phenobarbital-Induced but Not Basal Expression of the CYP2H1 Gene200310.1124/mol.63.1.732015-12-12