4-Alkoxycarbonyl- and aminocarbonyl-substituted isoxazoles as masked acrylates and acrylamides in the asymmetric synthesis of Δ 2 -isoxazolines

Lee, ConnieHerlt, AnthonySimpson, Gregory WayneWillis, AnthonyEaston, Christopher2015-12-130022-3263http://hdl.handle.net/1885/830184-Alkoxycarbonyl and aminocarbonyl-substituted isoxazoles undergo conjugate reduction to give Δ2-isoxazolines on treatment with sodium borohydride and sodium trifluoroacetoxyborohydride, respectively. They are also alkylated at C5 through sonication withKeywords: Acrylamides; Soxazolines; Tertiary alkyl iodides; Alkylation; Reaction kinetics; Reduction; Sodium compounds; Substitution reactions; Synthesis (chemical); Organic compounds; acrylamide derivative; acrylic acid derivative; aminocarbonyl derivative; carbon4-Alkoxycarbonyl- and aminocarbonyl-substituted isoxazoles as masked acrylates and acrylamides in the asymmetric synthesis of Δ 2 -isoxazolines200610.1021/jo06025692015-12-12