Anders, MichaelAnderson, WayneTzeng, Huey-FenBoard, Philip2015-12-132015-12-130009-2797http://hdl.handle.net/1885/89443Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of a range of α-haloalkanoates and the isomerization of maleylacetoacetate to furmarylacetoacetate. The elimination half-life of DCA is increased in human subjects or rats given singlKeywords: Dichloroacetate; Enzyme inactivation; Glutathione transferase zeta; Maleylacetoacetate isomerase20012015-12-12