Webb, AndrewDunstone, MichelleWilliamson, NicholasPrice, Jasonde Kauwe, AndreaChen, WeisanOakley, AaronPerlmutter, PatrickMcCluskey, JamesAguilar, Marie-IsabelRossjohn, JPurcell, Anthony2015-12-130022-1767http://hdl.handle.net/1885/81986A major hurdle in designing successful epitope-based vaccines resides in the delivery, stability, and immunogenicity of the peptide immunogen. The short-lived nature of unmodified peptide-based vaccines in vivo limits their therapeutic application in theKeywords: antigen; beta amino acid; cross reacting antigen; proteinase; vaccine; amino acid analysis; animal cell; article; cancer immunotherapy; controlled study; drug design; enzyme stability; epitope mapping; immunogenicity; immunoprophylaxis; in vivo study; maj20052015-12-11