Kang, Chol-HoHartmann, EnnoMenke, LisaStaudenraus, DanielAbass, ERaifer, HPorapu, AlekyaCamara, BBruestle, AnnePinkenburg, OlafBieringer, MariaLohoff, Michael2023-06-020014-2980http://hdl.handle.net/1885/292328We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon‐regulatory factor) C‐terminus creates hyperactive IRF4. When introduced into IRF4‐deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2‐linked IL‐13 production were much less altered.These studies were funded by the DFG (grant LO 396/8-1 to M.L.), the DZIF (M.L. and O.P.),Rh ̈on-Klinikum A.G, and Kempkes Stiftung(to M.B.application/pdfen-AU© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim201910.1002/eji.2018475302022-03-27